Toward antibody-catalyzed hydrolysis of organophosphorus poisons
نویسندگان
چکیده
منابع مشابه
Toward antibody-catalyzed hydrolysis of organophosphorus poisons.
We report here our preliminary results on the use of catalytic antibodies as an approach to neutralizing organophosphorus chemical weapons. A first-generation hapten, methyl-alpha-hydroxyphosphinate Ha, was designed to mimic the approach of an incoming water molecule for the hydrolysis of exceedingly toxic methylphosphonothioate VX (1a). A moderate protective activity was first observed on poly...
متن کاملA brain detoxifying enzyme for organophosphorus nerve poisons.
Organophosphorus (OP) insecticides and chemical warfare agents act primarily by inhibiting acetylcholinesterase. There are many secondary targets for OP toxicants as observed for example with the major insecticide chlorpyrifos and its bioactivated metabolite chlorpyrifos oxon (CPO). Therefore, it was surprising that the predominant mouse brain protein labeled in vitro by [(3)H-ethyl]CPO (1 nM) ...
متن کاملDNA-Catalyzed Amide Hydrolysis.
DNA catalysts (deoxyribozymes) for a variety of reactions have been identified by in vitro selection. However, for certain reactions this identification has not been achieved. One important example is DNA-catalyzed amide hydrolysis, for which a previous selection experiment instead led to DNA-catalyzed DNA phosphodiester hydrolysis. Subsequent efforts in which the selection strategy deliberatel...
متن کاملAutoantibody catalyzed hydrolysis of amyloid β peptide*
Autoantibody catalyzed hydrolysis of amyloid β peptide* Hiroaki Taguchi Stephanie Planque, Yasuhiro Nishiyama, Jindrich Symersky, Stephane Boivin, Paul Szabo, Robert P. Friedland, Paul A. Ramsland, Allen B. Edmundson, Marc E. Weksler, Sudhir Paul Chemical Immunology Research Center, Univ of Texas Houston Medical School, Houston, TX 77030, USA; Weill Medical College of Cornell University, New Yo...
متن کاملKinetics of Formic Acid-catalyzed Cellulose Hydrolysis
Hydrolysis is a reaction to produce sugars from lignocellulosic raw materials for biochemical production. The present study elucidates the hydrolysis of cellulose and formation of glucose decomposition products catalyzed by 5% to 20% (w/w) formic acid at 180 to 220 °C with an initial cellulose concentration of 10 to 100 g/L. Microcrystalline cellulose was used as a model compound. The experimen...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2000
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.97.13.7058